A sample letter is included below. You may copy and paste it into an email and send it to the following addresses: 

russell.blaisdell@nih.gov and annette.gilchrist@nih.gov

Subject: Support CADASIL Research Funding (x1biotech’s X101) 

Dear Dr. Blaisdell and Dr. Gilchrist,

I respectfully urge you to support NIH funding for groundbreaking CADASIL research that has the potential to lead to the first disease-modifying treatment for this devastating condition.

For those living with CADASIL, each stroke can bring permanent changes, and the disease often progresses through years of uncertainty, cognitive decline, and increasing disability. Many are diagnosed in the prime of their lives, forced to watch their independence, careers, and future plans gradually slip away. Their families experience these losses alongside them, hoping for a treatment that can change the course of the disease.

By preventing abnormal blood vessel growth and restoring normal vascular function, this treatment could preserve independence, protect cognitive function, reduce the risk of future strokes, and give hope to individuals and families who currently have no effective treatment options.  

NIH investment is essential to advancing promising research and moving potential therapies closer to patients. Support for projects such as x1biotech's X101 offers hope for changing the future for countless individuals and families affected by CADASIL.

Learn more: https://www.x1biotech.com

[Add your personal connection to CADASIL and why this research matters to you.]

Thank you for your time, consideration, and commitment to advancing medical research.

Sincerely,

[Your Name]

[City, State]